Comprehensive API Suite

(Includes all features from the Clinical Trial Matching API, Therapy Matching API, Annotations API, and Variant Interpretation API)

• Access curated content, including all biomarker-based clinical trials and therapies
• Review accurate & up-to-date variant data, including an extensive annotation data set that includes the latest variant information
• Integrate with a genomic model, and parse complex mutations, including protein expressions, chromosomal markers, and markers of genomic instability
• Access a disease ontology, and obtain an up-to-date, expandable disease hierarchy, disease codes, and institutional codes
• Evaluate clinical data, and track a patient’s medical history for patient treatment matching or for large scale analysis
• Included decision support to match patients to appropriate clinical trials, therapies, and prognoses
• The fully secure platform is compliant with all HIPAA protections, and can integrate with an existing security infrastructure

Clinical Trial Matching API

• Access all curated eligibilities, including all biomarker-based clinical trials curated through our in-house curation team and partnerships with leading content institutions
• Review relevant biomarker-based clinical trials that result from variant combinations or clinically significant alterations
• Integrate with clinical trial matching systems to prioritize and match to institutional trials
• Evaluate the curated eligibility criteria, matched variants and diseases, phases, and recruiting status of each “matched” trial
• View trial results within any specified radius based on a patient’s zip code or a specific institutional zip code
• Filter through matched trial results by drug names, variants, diseases, and phase
• View a list of clinical trials that a patient would be eligible for if additional genomic criteria are tested for


Therapy Matching API

• Investigate comprehensive coverage of drug approvals and biomarker-directed guidelines, including the detailed annotation of FDA label text, companion diagnostics, line of therapy, disease status, and NCCN categories of evidence and preference
• Review the clinical trial results that underlie all approvals and guidelines, as well as published evidence related to investigational therapies, primarily from the Jackson Laboratory Clinical Knowledgebase (JAX-CKB)
• Access all gene / alteration targets that identify relevant therapies that do not have existing evidence
• Evaluate each therapy result, including a list of recruiting clinical trials in which the patient could access the therapy, sorted by distance to the patient, regardless of whether the trial has molecular eligibility requirements
• Analyze a list of relevant therapy results for the patient that are sorted by level of evidence, including approval and guideline status, to streamline the therapy selection process

Annotations API

• Includes ten open-sourced and licensed annotation data sets, with the option to scale with an institution’s proprietary and licensed data sets
• Annotation data sets are fully-vetted by GenomOncology’s Quality Assurance processes prior to distribution
• Optimized and scalable for high-throughput requirements, such as labs performing Whole Exome Sequencing and Whole Genome Sequencing
• Access the latest information available in the annotation data set with scheduled quarterly updates
• A Command Line Interface (gocli) can be dropped into an existing bioinformatics pipeline to add annotation and filtering capabilities
• Access numerous data sets, including HGVS/RefSeq, COSMIC, ExAC, GNOMAD, HPO, REVEL, clinvar, dbNSFP, dbSNP, and mitomap

Variant Interpretation API

• Determine variant significance to identify the key variants for each case
• Interpretation based on one or more fully customizable, flow chart-like templates
• Templates can be based on any annotation (ClinVar, gnomAD, COSMIC, PolyPhen, etc) or assertion (therapies, clinical trials, prognostic associations, etc) in the database
• The full path of the variant through the interpretation template is included in the response, so the reasoning behind each interpretation is clear
• Optimized and scalable for high-throughput annotation, such as whole exome and whole genome sequencing